Endocrine kusagadzikana inokonzerwa nehutano hwakawanda hwehutachiona hunokonzera kusakanganiswa kwemafuro kana kusakwana kwavo zvachose kuvakadzi. Mune varume, izvi zvirwere zvinoratidzirwa nekuputsika kwepermatogenesis uye kuderera kwehutano hwehuta. Pamwoyo we endocrine kusununguka kunokanganisa mukushanda kwetachiona gland, hypothalamic-pituitary system, gonads.
Kurapa kwenguva yakafanira kwezvinetso zvakadaro mumuviri kunotungamirira pakutanga kwekuda kuzvitakura muna 70-80% yezvose zvinokonzera endocrine infertility. Kana zvisina kudaro, nzira chete yekubudirira kubata pamuviri wemwana ndiyo nzira ye in vitro fertilization. Kusarudzwa kwemuitiro wekushaya rubatsiro kunogadziriswa chete mushure mekuongororwa kwakazara kwevakaroorana. Zvakakosha kuti vaviri vakaroorana vapedzise kuongorora uye kuongorora. Uye sezvo zvichigona kuonekwa zvinokonzera zvakasiyana-siyana zvekuputsa kwemabasa ekuberekorora, chirwere chinowanzotanga nezvikonzero izvo zvinokosha zvikuru pakuita pamuviri.
Therapy ye endocrine infertility inofanira kusiyaniswa uye yakasarudzwa mumwe nomumwe. Zvinokonzerwa nekusarudza nzira yekurapa ndezvi: zvinokonzera, nguva yekusabereka, kuvapo kwezvirwere zvinokonzera.
Kusagadzikana kwechikwata chekateti
Chimwe chezvikonzero zvinokonzera kuputsa kwechivhota. Izvi zvirwere zvinosanganisira kusagadzikana kwekushanda kwemuviri wemiviri, zvichikonzera kuchinja kwekunyora mu endometrium. Mune mamwe mazwi, endometrium yakadaro haina kukodzera ovum inogadzirwa. Pathology inogona kukura nokuda kwezvikonzero zvakasiyana-siyana: nemhaka yehutachiona hutachiona, hutano hwe hyperprolactinemia, kusingaperi kusuruvara kwezvikadzi, hyperandrogenism. Kakawanda nguva dzose, kurapwa kunotanga nekushandiswa kwe estrogen-progestogen, iyo inobatsira kuti uwane huvhu. Kazhinji kongodaro kusangana pamwe chete kwakagadzirirwa. Nguva yekutambira kwavo ndeye 3-5 maitiro. Mune ramangwana, zvinokwanisika kuitisa kurapwa uchishandura zvakananga kukurudzira kweivulation.
Mukusakosha kwechiitiko chakanaka, maigadziro ane gonadotropic hormone (menogon, humegon) anowanikwa mumutambo wekurapa, uye chorionic gonadotropin inotarisirwa mune chirwere chechirwere chiri pasi pehutungamiri hukuru. Kana kusagadzikana kwechikwata chekuteerera kunokonzerwa ne hyperprolactinemia kana hyperandrogenism, saka ergotid alkaloids kana dexamethasone (norprolac, parlodel) inowanirwa zvakare.
Syndrome of chronic anovulation
Izvi zvirwere zvinogona kukonzerwa nezvirwere zve endocrine zvakadai se hyperprolactinemia yevasina tumarara uye chiremara chinotangira, polycystic ovary syndrome, hyperandrogenism yeadrenal yakabva, hypothalamic-pituitary kusagadzikana, uyewo chirwere chekudzivirira mazai kana chirwere chemavhaya anopera. Chinangwa chekurapa kwezvinetso zvakadaro ndechokurudzira ovulation. Muchiitiko che polycystic ovary syndrome, kukanganisa kwekudzivirira kunotanga kuwanikwa, uye zvino kuvhara maawa kunowedzera kushandiswa uchishandisa gonadotropin kana anti-estrogen. Nguva yekurapa nehomoni inokwana 3-5 maitiro. Mukusabatwa kwechiitiko chakanaka, kupindira kwekuvhiya kunoitwa nenzira yekodha resection, mairi maviri evarian biopsy, uye electrocautery yemashizha. Aya maitiro anoshandiswa neparparcopy access.
Nokukurumidza kupera kwemavha mavari uye nekuvandudzika kwemasinga mazamu, kushandiswa kwemaitiro kusingabatsiri. Nokudaro, kushandiswa kwekushaya rubatsiro kunoitwa kuburikidza uchishandisa maii anopa mavhesi ekusimba kwechirongwa chekugadzirisa, iyo yakagadziridzwa kuburikidza nokuiswa kwe in vitro fertilization uye embryo kuendesa teknolojia kuchipatara.
Muchirapa kune pfungwa yokuti 100% kubudirira mukurapa kwehomoni inoberekwa kunogona kutarisirwa nehutano hwakarongeka hwakarongeka uye mumamiriro ezvinhu apo kuputsa kwekuvhunga kunokonzerwa nechikonzero chimwe chete mumhuri. Asi pakuita chiito ichi chinenge chiri pasi uye chiri 60-70%.